PKM2-IN-1 | PKM2 inhibitor | Probechem Biochemicals

Chemical Structure : PKM2-IN-1

CAS No.: 94164-88-2

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PKM2-IN-1 (Compound 3k)

货号: PC-25405Not For Human Use, Lab Use Only.

PKM2-IN-1 (Compound 3k) is a potent small moleculepyruvate kinase M2 (PKM2) inhibitor with IC50 of 2.95 uM, with less inhibition of PKM1 and PKL.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg		Get quote

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生物&药学活性

PKM2-IN-1 (Compound 3k) is a potent small molecule pyruvate kinase M2 (PKM2) inhibitor with IC50 of 2.95 uM, with less inhibition of PKM1 and PKL.
PKM2-IN-1 (Compound 3k) shows nanomolar antiproliferative activity toward a series of cancer cell lines with high expression of PKM2 including HCT116, Hela and H1299 with IC50 values ranging from 0.18 to 1.56 μM.
PKM2-IN-1 (Compound 3k) exhibits more cytotoxicity on cancer cells than normal cells.

物理化学性质&存储条件

分子量	345.48
分子式	C18H19NO2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3-Methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl piperidine-1-carbodithioate

参考文献

1. Ning X, et al. Eur J Med Chem. 2017 Sep 29;138:343-352.

PKM2-IN-1 (Compound 3k)

生物&药学活性

物理化学性质&存储条件

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PKM2-IN-1 (Compound 3k)

生物&药学活性

物理化学性质&存储条件

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