| Cat. No. |
Product Name |
Information |
| PC-49812 |
ML146
NOD1 inhibitor
|
ML146 (ML-146, Pubmed CID-1088438) is a selective small molecule NOD1 inhibitor with IC50 of 1.5 uM in NOD1 agonist-stimulated NF-κB reporter assay in HEK293T cells. |
| PC-49811 |
GSK223
NOD1 inhibitor
|
GSK223 (GSK-223) is a specific small molecule inhibitor of the NOD1 signaling pathway, shows NOD1 inhibitory activity with IC50 of 1 uM in 293/hNOD1 cell assays, does not inhibit RIP2 kinase. |
| PC-49809 |
FK 156
NOD1 agonist
|
FK156 is an immunoactive peptide and a nucleotide-binding oligomerization domain (Nod)-1 ligand agonist. |
| PC-49808 |
FK 565
NOD1 agonist
|
FK565 is an immunoactive peptide and a nucleotide-binding oligomerization domain (Nod)-1 ligand agonist. |
| PC-49807 |
Muramyl Dipeptide
NOD2 agonist
|
Muramyl Dipeptide (MurNAc-L-Ala-gamma-D-Glu, MDP) is a naturally occurring component of bacterial cell walls that has the capacity to activate macrophages, is an immunological adjuvant, is an inducer of bone formation through induction of RUNX2, directly enhances osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways, activates the NOD2-RIP2 signaling axis. |
| PC-49463 |
NIC7
NLRP3 inhibitor
|
NLRP3-inhibitory compound 7 (NIC7) is a small-molecule inhibitor of Nod-like receptor family pyrin domain-containing 3 (NLRP3), inhibits NLRP3-mediated activation of caspase 1 along with the secretion of IL-1β, IL-18, and lactate dehydrogenase. |
| PC-49396 |
GDC-2394
NLRP3 inhibitor
|
GDC-2394 (GDC2394) is a potent and selective NLRP3 inhibitor with IC50 of 5.4 nM (IL-1β inhibition in PBMCs). |
| PC-49268 |
NDT-30805
NLRP3 inhibitor
|
NDT-30805 is a potent and selective small molecule NLRP3 inflammasome inhibitor with IC50 of 13 nM for IL-1β inhibition in PBMCs. |
| PC-38558 |
GSK669
NOD2 inhibitor
|
GSK669 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor, inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling (IC50=0.5 uM), has an IC50 of 3.2 uM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells. |
| PC-38557 |
GSK717
NOD2 inhibitor
|
GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor, inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, has an IC50 of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells. |
| PC-38421 |
Selnoflast
NLRP3 inhibitor
|
Selnoflast (RO7486967, RG-6418, IZD334) is a potent, selective, reversible and orally active small molecule NLRP3 inflammasome inhibitor. |
| PC-73216 |
NLRP3-IN-3
NLRP3 inhibitor
|
NLRP3-IN-3 is a potent and selective inhibitor of NLRP3 inflammasome with IC50 of 1.26 nM in THP1 cells, showing good pharmacokinetic profiles with oral bioavailability. |
