Selnoflast (RO7486967, RG-6418, IZD334)

Chemical Structure : Selnoflast

CAS No.: 2260969-36-4

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货号: PC-38421Not For Human Use, Lab Use Only.

Selnoflast (RO7486967, RG-6418, IZD334) is a potent, selective, reversible and orally active small molecule NLRP3 inflammasome inhibitor.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

Selnoflast (RO7486967, RG-6418, IZD334) is a potent, selective, reversible and orally active small molecule NLRP3 inflammasome inhibitor.

Selnoflast (RO7486967, RG-6418, IZD334) inhibits IL-1β release stimulated by NLRP3 activation in human Alzheimer's disease (AD) monocyte-derived macrophages.

Selnoflast (RO7486967, RG-6418, IZD334) shows potential for treatment of AD and systemic inflammatory diseases, such as ulcerative colitis and chronic obstructive pulmonary disease.

物理化学性质&存储条件

分子量	391.530
分子式	C20H29N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-ethyl-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)piperidine-4-sulfonamide

参考文献

1. Patent WO2019008025 A1.