| Cat. No. |
Product Name |
Information |
| PC-21211 |
GSK-J4
KDM6A/6B inhibitor
|
GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively, GSK-J4 s a cell permeable prodrug of GSK-J1. |
| PC-21085 |
JMJD5 inhibitor 19j
JMJD5 inhibitor
|
JMJD5 inhibitor 19j is a potent selective small molecule inhibitor of 2OG-dependent oxygenase JMJD5 (KDM8), shows high selectivity over other human 2OG oxygenases. |
| PC-20876 |
ZY0511
LSD1 inhibitor
|
ZY0511 is a highly selective and potent inhibitor of lysine-specific histone demethylase 1 (LSD1) with IC50 of 1.7 nM and SPR Kd of 2.42 nM. |
| PC-20519 |
TAK-418
LSD1 inhibitor
|
TAK-418 (TAK418) is a potent, specific inhibitor of LSD1 (KDM1A) enzyme activity with IC50 of 2.9 nM. |
| PC-20355 |
KDM5B inhibitor 27ab
KDM5B inhibitor
|
KDM5B inhibitor 27ab is a potent inhibitor of histone lysine specific demethylase 5B (KDM5B/JARID1B) with IC50 of 24.4 nM. |
| PC-20354 |
KDM5A inhibitor compound 1
KDM5A inhibitor
|
KDM5A inhibitor compound 1 (ZINC33576) is a potent, selective KDM5A (JARID1A) inhibitor with IC50 of 23.8 nM. |
| PC-20353 |
CBA-1
KDM3A inhibitor
|
CBA-1 is a small molecule inhibitor of Wnt signaling, specifically targets Jumonji (JmjC) domain-containing demethylase KDM3A with IC50 of 3.9 uM. |
| PC-20352 |
EPZ020809
KDM4C inhibitor
|
EPZ020809 is a potent, specific KDM4C inhibitor with Ki of 31 nM, binds KDM4C in a 2-OG-competitive fashion. |
| PC-20255 |
Bomedemstat
LSD1 inhibitor
|
Bomedemstat (IMG-7289) is a potent, selective, irreversible and orally active LSD1 (KDM1A) inhibitor, increases H3K4 and H3K9 methylation. |
| PC-49244 |
iJMJD6
JMJD6 inhibitor
|
iJMJD6 is a potent, specific small-molecule JMJD6 inhibitor that specifically binds to JMJD6 (ITC Kd=3.83 uM) and competes with α-KG and the substrate for binding, inhibits the demethylase activity of JMJD6 with IC50 of 149.6 nM. |
| PC-49236 |
FTO-43
FTO inhibitor
|
FTO-43 (FTO-43 N) is a potent, selective inhibitor of the m6A demethylase fat mass- and obesity-associated protein (FTO) with IC50 of 1.0 uM, no significant acitivity against the homologous m6A RNA demethylase ALKBH5 (IC50>40 uM). |
| PC-38672 |
Pulrodemstat benzenesulfonat
LSD1 inhibitor
|
Pulrodemstat (CC-90011) is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with biochemical IC50 of 0.3 nM. |
