| Cat. No. |
Product Name |
Information |
| PC-22985 |
YTH domain inhibitor N-7
m6A YTH domain inhibitor
|
YTH domain inhibitor N-7 is a specific small molecule, pan-inhibitor of YTH domain-containing m6A RNA readers with IC50 of 30-48 uM for human YTHDF1, YTHDF2, YTHDF3, YTHDC1, and YTHDC2 proteins. |
| PC-22960 |
ML234
EZH2/LSD1 inhibitor
|
ML234 is a potent EZH2/LSD1 dual inhibitor with IC50 of 0.09/0.12 uM respectively, shows excellent antiproliferative capacity against prostate cancer cell lines LNCAP, PC3, and 22RV1. |
| PC-22951 |
GSK-J5
|
GSK-J5 is the ethyl ester pro-drug of GSK-J2, which lacks H3K27 demethylase activity as a inactive control molecule for GSK-J4. |
| PC-22581 |
TACH101 L-lysine
KDM4 inhibitor
|
TACH101 (Zavondemstat, QC8222, TACH 101) L-lysine is a reversible, α-ketoglutarate competitive, selective and potent inhibitor of KDM4 isoforms A-D with IC50 values of 80 nM against all four isoforms. |
| PC-22360 |
KDM4/5 inhibitor 19a
KDM4/5 inhibitor
|
KDM4/5 inhibitor 19a is a potent, cell penetrant, dual KDM4/5-subfamily inhibitor with Ki values of 4 nM/7 nM for KDM4A/KDM5B, respectively. |
| PC-22359 |
N19-0881
KDM5B inhibitor
|
KDM5-N19 (N19-0881) is a potent, selective, αKG-competitive KDM5B inhibitor with IC50 of 2 nM. |
| PC-22357 |
2,4-PDCA
2OG oxygenase inhibitor
|
2,4-PDCA (2,4 pyridine dicarboxylic acid) is a broad-spectrum inhibitor of 2OG oxygenases, including JmjC domain-containing family of histone demethylases (JHDMs), shows acceptable KDM5B inhibition in vitro, with an IC50 value of 3 uM. |
| PC-21988 |
KDOAM-25 citrate
KDM5 inhibitor
|
KDOAM-25 citrate (KDM5 inhibitor KDOAM 25) is a potent, selective KDM5 sub-family (JARID1) inhibitor with biochemical IC50 of 71/19/69/69 nM for KDM5A/B/C/D, respectively. |
| PC-21777 |
JMJD1C inhibitor 193D7
JMJD1C inhibitor
|
193D7 is a specific and oral inhibitor of histone demethylase JMJD1C with IC50 of 0.59 uM in in vitro demethylation assays, suppresses tumor growth by targeting intratumoral Treg cells. |
