| Cat. No. |
Product Name |
Information |
| PC-26342 |
Naperiglipron
GLP-1R agonist
|
Naperiglipron (LY3549492) is a highly potent Glucagon-like peptide 1 receptor (GLP-1R) agonist with EC50 of 1.14 nM for hGLP-1R. |
| PC-25613 |
AZD0186
GLP-1R agonist
|
AZD0186 is a potent, selective glucagon-like peptide-1 receptor (GLP-1R) agonist, shows concentration-dependent potentiation of GSIS in EndoC-βH5 cells with EC50 of 0.6 nM, improves glucose control and reduces body weight. |
| PC-25477 |
Exendin-P5
GLP-1R agonist
|
Exendin-P5 (ExP5) is a potent, selective, G protein-biased peptide agonist of GLP-1 receptor (GLP-1R), with diminished coupling to β-arrestins. |
| PC-24419 |
DA-302168S
GLP-1R agonist
|
DA-302168S is a potent, selective and orally bioavailable agonist of GLP-1R with EC50 of 1.32 nM in luciferase assay in HEK293 cells expressing hGLP-1R. |
| PC-23689 |
Survodutide
GCGR/GLP-1R agonist
|
Survodutide (BI 456906) is a highly potent GCGR/GLP-1R dual agonist with EC50 of 0.52/0.60 nM respectively (human GCGR/GLP-1R), exhibits robust weight loss and glycaemic control activity. |
| PC-23685 |
GLP-1 receptor agonist 2
GLP-1 agonist
|
GLP-1 receptor agonist 2 is a potent, selective GLP-1 receptor agonist, shows potential for GLP-1 receptor - mediated diseases, such as pre-diabetes, type II diabetes, non-alc. steatohepatitis, non-alc. fatty liver disease, obesity, cardiovascular and other diseases. |
| PC-23574 |
Avexitide
GLP-1R antagonist
|
Avexitide (Exendin-(9-39)) is a selective glucagon-like peptide 1 receptor (GLP-1R) antagonist, competes with endogenous GLP-1 for binding to GLP-1 receptors with Ki of 4.0 nM. |
| PC-23495 |
BETP
GLP-1 agonist
|
BETP is a potent, allosteric activator/agonist of glucagon-like peptide-1 (GLP-1) receptor with EC50 of 0.66 and 0.755 μM for human and rat GLP-1 receptor, respectively, also inhibits importin α1 import and importin β1 dependent cargo import with EC50 of μM uM in phenotypic importin α1 translocation assays. |
| PC-21204 |
Teduglutide
GLP-2 analogue
|
Teduglutide (ALX-0600, h[Gly(2)]GLP-2) is a dipeptidyl peptidase IV resistant GLP-2 analogue, prolongs the intestinotrophic properties of GLP-2 in animal models. |
| PC-72602 |
Cotadutide acetate
Dual GLP-1/glucagon receptor agonist
|
Cotadutide acetate (MEDI-0382, MEDI0382) is a potent dual GLP-1/glucagon receptor peptide agonist with EC50 values of 6.9 pM and 10.2 pM, respectively. |
| PC-20600 |
RGT1383
GLP-1R agonist
|
RGT1383 is a small molecule GLP-1R agonist, RGT1383 is a full agonist in G protein-mediated cAMP signaling with EC50 of 0.2 nM, and a partial agonist in β-arrestin-mediated signaling. |
| PC-20512 |
LSN3318839
GLP-1R PAM
|
LSN3318839 is a potent, positive allosteric modulator of glucagon-like peptide-1 receptor (GLP-1R) with EC50 of 14 nM, Emax of 104%. |
