| Cat. No. |
Product Name |
Information |
| PC-42545 |
AV-412
EGFR inhibitor
|
AV-412 (MP 412) is a potent dual inhibitor of EGFR and ErbB2, inhibits EGFR/EGFR L858R/EGFR T790M/EGFR L858R, T790M/ErbB2 with IC50 of 1.5/0.5/0.8/2.3/19 nM respectively. |
| PC-45479 |
PD158780
EGFR inhibitor
|
PD158780 is a highly potent, selective, ATP binding site inhibitor of EGFR with IC50 of 8 nM. |
| PC-45995 |
Mutated EGFR-IN-1
EGFR inhibitor
|
Mutated EGFR-IN-1 is an analogue of AZD9291 that is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant. |
| PC-27403 |
FHND9041
EGFR T790M inhibitor
|
Adonertinib (FHND9041) is a third-generation, irreversible EGFR T790M mutation-selective inhibitor, selectively inhibitsphosphorylation of EGFR mutant kinase and the activation of its downstream key signaling molecules, Akt and Erk, thereby inhibiting the proliferation of tumor cells with EGFR T790M resistance or sensitive mutations and inducing apoptosis of tumor cells. |
| PC-27288 |
ZW-49
EGFR inhibitor
|
ZW-49 is a potent, selective and covalent inhibitor of all subgroups of EGFR mutations with IC50 of 1.5 nM (EGFR L858R/T790M), potently inhibits all subgroups of EGFR mutations with selectivity over wild-type EGFR and other target families. |
| PC-26663 |
SH-1092
EGFR inhibitor
|
SH-1092 is a potent third generation EGFR inhibitor with IC50 of 0.96 nM and 6.1 nM for EGFR(T790M/L858R) and EGFR(WT) respectively. |
| PC-26083 |
JIN-A02
EGFR C797S inhibitor
|
JIN-A02 is a potent, mutant-selective, orally available fourth-generation EGFR tyrosine kinase inhibitor (EGFR-TKI), overcomes C797S-mediated resistance. |
| PC-25853 |
NSC228155
EGFR activator, CREB-CBP inhibitor
|
NSC228155 (NSC 228155) is a potent inhibitor of CREB-CBP interaction (IC50=0.36 uM) taregting interaction of kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP, also is an activator of EGFR, binds to the extracellular region of EGFR and enhances tyrosine phosphorylation of EGFR. |
| PC-25509 |
Tarloxotinib
pan-HER inhibitor
|
Tarloxotinib (TH-4000) is a hypoxia-activated pan-HER inhibitor, generates the active form TH-4000Effector (TH-4000E) under hypoxic condition, TH-4000E selectively inhibits EGFR, HER2 and HER4 with IC50 of <1 nM. |
| PC-24940 |
Genistein
Hsp90β inhibitor
|
Genistein (NPI 031L) is a soy isoflavone and multiple tyrosine kinases (e.g., EGFR, MKK4 (IC50=400 nM)) inhibitor, Genistein is a chemotherapeutic agent against different types of cancer. |
| PC-24922 |
EGFR-targeting peptide GE11
EGFR ligand
|
EGFR-targeting peptide GE11 is an epidermal growth factor receptor (EGFR)-specific ligand for active targeting of EGFR-overexpressing cancer cells, Conjugation of GE11 peptides to liposomal constructs enhances anti-tumor efficacies and specificities in laryngeal cancer cells. |
| PC-24584 |
ELF3-MED23 interaction inhibitor YK1
ELF3-MED23 inhibitor
|
YK1 is a potent and selective PPI inhibitor for ELF3-MED23 with IC50 of 1.18 uM, 95 % inhibition at 10 uM, attenuates the HER2-mediated oncogenic signaling cascades. |
