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首页-小分子抑制剂&激动剂-Tyrosine Kinase-EGFR-FHND9041
FHND9041

Chemical Structure : FHND9041

CAS No.: 2211116-92-4

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FHND9041 (Adonertinib, FHND-9041)

货号: PC-27403Not For Human Use, Lab Use Only.

Adonertinib (FHND9041) is a third-generation, irreversible EGFR T790M mutation-selective inhibitor, selectively inhibitsphosphorylation of EGFR mutant kinase and the activation of its downstream key signaling molecules, Akt and Erk, thereby inhibiting the proliferation of tumor cells with EGFR T790M resistance or sensitive mutations and inducing apoptosis of tumor cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Adonertinib (FHND9041) is a third-generation, irreversible EGFR T790M mutation-selective inhibitor, selectively inhibitsphosphorylation of EGFR mutant kinase and the activation of its downstream key signaling molecules, Akt and Erk, thereby inhibiting the proliferation of tumor cells with EGFR T790M resistance or sensitive mutations and inducing apoptosis of tumor cells.

物理化学性质&存储条件

分子量 528.68
分子式 C30H32D3N7O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Propenamide, N-[5-[[4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-2-pyrimidinyl]amino]-4-methoxy-2-[[2-(methylmethyl-d3-amino)ethyl]methylamino]phenyl]-

参考文献

1. Lu C, et al. BMC Pharmacol Toxicol. 2025 May 7;26(1):97.

2. Zeng L, et al. Lung Cancer. 2025 Sep;207:108684.

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