| Cat. No. |
Product Name |
Information |
| PC-27409 |
CT7439
CDK12/13 inhibitor, Cyclin K degrader
|
CT7439 (CT-7439) is a potent, selective and oral cyclin-dependent kinases CDK12/CDK13 inhibitor and monovalent glue degrader of cyclin K (CCNK), inhibites OV-90 cell growth with IC50 of 4.4 nM. |
| PC-27232 |
Cdc7 inhibitor 89S
CDC7 inhibitor
|
Cdc7 inhibitor 89S is a potent, ATP mimetic inhibitor of Cdc7 kinase with Ki of 0.5 nM, inhibits cell proliferation of different tumor cell lines with IC50 in submicromolar range, and exhibits in vivo tumor growth inhibition of 68% in the A2780 xenograft model. |
| PC-27231 |
XL413
CDC7 inhibitor
|
XL413 (BMS-863233) is a potent, selective, ATP competitive serine/threonine kinase CDC7 inhibitor with IC50 of 3.4 nM. |
| PC-26497 |
RO8323
CDK8/19 inhibitor
|
RO8323 is a potent and selective dual CDK8/19 inhibitor with IC50 of 2/3 nM respectively, has 100-fold kinome selectivity. |
| PC-26429 |
CDK11 inhibitor 37
CDK11 inhibitor
|
CDK11 inhibitor 37 is a potent, selective CDK11 inhibitor with IC50 of 4 nM, exhibits clean kinome selectively. |
| PC-26368 |
CDK9 inhibitor C35
CDK9 inhibitor
|
CDK9 inhibitor C35 is a potent, selective and orally bioavailable CDK9 inhibitor with IC50 of 17.44 nM, shows 18-fold selectivity over CDK2. |
| PC-26367 |
CDK9 inhibitor HS34
CDK9 inhibitor
|
CDK9 inhibitor HS34 is a potent, selective CDK9 inhibitor with IC50 of 1.4 nM (CDK9/CycT1), shows 250-fold selectivity over CDK2/CycA2. |
| PC-26363 |
Vustanaciclib
CDK2/4/6 inhibitor
|
Vustanaciclib (GDC-4198, RGT-419B) is a potent CDK2/4/6 inhibitor. |
| PC-26145 |
HQY1428
cyclin K degrader
|
HQY1428 is an oral availabile cyclin K molecular glue degrader, promotes CDK12 condensation in nuclear speckles and accelerates proteasomal degradation of CDK12-cyclin K, shows potent single-agent antitumor activity and synergistic efficacy with HER2 inhibitors. |
| PC-25879 |
ZLY025
cyclin K degrader
|
ZLY025 is a highly potent, selective Cyclin K (CCNK) degrader with DC50 of 42.7 nM and Dmax>93%, exhibits broad-spectrum antitumor activity. |
| PC-25728 |
NU6140
CDK2 inhibitor
|
NU6140 is a selective inhibitor of CDK2 with IC50 of 0.41 uM for CDK2-cyclin A, 10- to 36-fold selective for CDK2-cyclin A over the other CDKs. |
| PC-25672 |
LCI133
CDK4/6/9, AURKA/B inhibitor
|
LCI133 is a highly potent, selective multikinase CDK4/6/9 and AURKA/B inhibitor with IC50 of 4.7/10.2/4.1 nM for CDK4/6/9 and 2.8/10.6 nM for AURKA/B. |
