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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-Cucurbitacin E
Cucurbitacin E

Chemical Structure : Cucurbitacin E

CAS No.: 18444-66-1

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Cucurbitacin E (α-Elaterin, α-Elaterine)

货号: PC-27637Not For Human Use, Lab Use Only.

Cucurbitacin E (α-elaterin) is a strong antifeedant natural compound with the ability to disrupt cell actin and cell adhesion, induces CRC G2/M phase arrest via cell division cycle gene 2 (CDC2) downregulation and dissociation of the cyclin B1/CDC2 complex.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Cucurbitacin E (α-elaterin) is a strong antifeedant natural compound with the ability to disrupt cell actin and cell adhesion, induces CRC G2/M phase arrest via cell division cycle gene 2 (CDC2) downregulation and dissociation of the cyclin B1/CDC2 complex.
Cucurbitacin E inhibits cell survival/proliferation of primary CRC cell lines.
Cucurbitacin E-induced cell cycle arrest in CRC cells occurs via a mechanism other than the accumulation of intracellular ROS.
Cucurbitacin E induces accumulation of G2/M phase in CRC cells.
Cucurbitacin E induces G2/M arrest in CRC cells via integration of GADD45 γ with CDC2.
Cucurbitacin E also induces PANoptosis in adrenocortical carcinoma cells in a ZBP1-dependent manner.

物理化学性质&存储条件

分子量 556.70
分子式 C32H44O8
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R,E)-6-((8S,9R,10R,13R,14S,16R,17R)-2,16-Dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-4,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetate

参考文献

1. Hsu YC, et al. Cell Death Dis. 2014 Apr 24;5(4):e1198.

2. Murtaza M, et al. PLoS One. 2017 Jun 9;12(6):e0178910.

3. Hung CM, et al. Sci Rep. 2014 Sep 23;4:6454.

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