| Cat. No. |
Product Name |
Information |
| PC-25678 |
Lubiprostone
Chloride channel activator
|
Lubiprostone (SPI-0211) is a potent, selective type 2 chloride channel (CLC-2) activator, increases electrogenic Cl- transport across the apical membrane of T84 cells with EC50 of 18 nM. |
| PC-25157 |
Fluralaner
GABA-Cls inhibitor
|
Fluralaner is a systemic insecticide and acaricide through potent blockage of GABA and L-glutamate gated chloride channels. |
| PC-25156 |
Tigolaner
GABA-Cls inhibitor
|
Tigolaner (BAY-1272858) is a potent, allosteric modulator/ inhibitor of GABA-gated chloride channels (GABA-Cls) with pIC50 of 9.0. |
| PC-24829 |
NPPB
Chloride channel blocker
|
NPPB is a nonspecific chloride channel blocker, inhibits outward rectifying chloride currents (ORCC), suppresses glioma cell migration and invasion. |
| PC-23810 |
Tamsulosin
TMEM16A inhibitor
|
Tamsulosin ((R)-(-)-YM12617 free base) is an inhibitor of α1-adrenergic receptor, also demonstrates significant antiosteoporotic effects by inhibiting calcium-activated chloride channel TMEM16A. |
| PC-23489 |
ClC-1 inhibitor Compound A-3
ClC-1 channel inhibitor
|
ClC-1 inhibitor Compound A-3 is a specific inhibitor of skeletal muscle-specific chloride ion (Cl-) channel ClC-1 with IC50 of 2.3 uM for reduction in the Cl- driven membrane conductance (Gm). |
| PC-22008 |
NMD670 sodium
ClC-1 inhibitor
|
NMD670 (NMD-670) sodium salt is a potent, specific and orally bioavailable ClC-1 chloride channel inhibitor with EC50 of 1.6 uM, restores muscle function in rat models of myasthenia gravis (MG). |
