Tigolaner | GABA-Cls inhibitor | Probechem Biochemicals

Chemical Structure : Tigolaner

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Tigolaner (BAY-1272858, BAY1272858)

货号: PC-25156Not For Human Use, Lab Use Only.

Tigolaner (BAY-1272858) is a potent, allosteric modulator/ inhibitor of GABA-gated chloride channels (GABA-Cls) with pIC50 of 9.0.

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生物&药学活性

Tigolaner (BAY-1272858) is a potent, allosteric modulator/ inhibitor of GABA-gated chloride channels (GABA-Cls) with pIC50 of 9.0.
Tigolaner inhibits GABA-gated chloride channels at a different binding site to fipronil.
Tigolaner is an ectoparasiticide for cats and is sold in a mixture product with emodepside and praziquantel called Felpreva®.

物理化学性质&存储条件

分子量	552.81
分子式	C21H13ClF8N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, 2-chloro-N-(1-cyanocyclopropyl)-5-[1'-methyl-3'-(1,1,2,2,2-pentafluoroethyl)-4'-(trifluoromethyl)[1,5'-bi-1H-pyrazol]-4-yl]-

参考文献

1. Décor A, et al. Bioorg Med Chem Lett. 2025 Jul 29:130352.

Tigolaner (BAY-1272858, BAY1272858)

生物&药学活性

物理化学性质&存储条件

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Tigolaner (BAY-1272858, BAY1272858)

生物&药学活性

物理化学性质&存储条件

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