| Cat. No. |
Product Name |
Information |
| PC-45823 |
AMD-070
CXCR4 antagonist
|
Mavorixafor (AMD-070, AMD-11070) is a potent and selective antagonist of CXCR4 with IC50 of 13 nM in a CXCR4 125I-SDF inhibition binding assay. |
| PC-42391 |
IT1t dihydrochloride
CXCR4 inhibitor
|
IT1t (Isothiourea 1t) dihydrochloride is a highly potent, selective, orally bioavailable CXCR4 inhibitor with binding IC50 of 8 nM for hCXCR4, IC50 of 1.1 nM in Ca2+-mobilization assays. |
| PC-42390 |
IT1t
CXCR4 inhibitor
|
A highly potent, selective, orally bioavailable CXCR4 inhibitor with binding IC50 of 8 nM for hCXCR4, IC50 of 1.1 nM in Ca2+-mobilization assays. |
| PC-25858 |
VUF16840
ACKR3 inverse agonist
|
VUF16840 is a potent and selective small-molecule inverse agonist of ACKR3 (CXCR7), displaces CXCL12-A647 binding to NLuc-hACKR3 with IC50 of 7 nM, suppresses constitutive signaling of ACKR3. |
| PC-24281 |
trans-VUF25471
ACKR3 agonist
|
trans-VUF25471 is a small moleculephotoswitchable atypical chemokine receptor 3 (ACKR3) agonist, can be effectively switched from its thermodynamically stable trans state to the less active cis-isomer with a photostationary state of 96%. |
| PC-24136 |
Fosrugocrixan
CX3CR1 antagonist
|
Fosrugocrixan is a potent, selective antagonist of CX3C chemokine receptor 1 (CX3CR1) with antiinflammatory activity. |
| PC-24077 |
IDOR-1136-517
CCR8 antagonist
|
IDOR-1136-5177 is a highly potent, selective CCR8 antagonist with IC50 of 2 nM (hCCR8). |
| PC-23972 |
Reparixin L-lysine salt
CXCR1/2 inhibitor
|
Reparixin L-lysine salt (Repertaxin) is a potent, selective, non-competitive allosteric inhibitor of CXCL8 receptor CXCR1 and CXCR2 activation with IC50 of 1 nM and 100 nM, respectively. |
| PC-23971 |
Reparixin
CXCR1/2 inhibitor
|
Reparixin (Repertaxin) is a potent, selective, non-competitive allosteric inhibitor of CXCL8 receptor CXCR1 and CXCR2 activation with IC50 of 1 nM and 100 nM, respectively. |
| PC-23688 |
RS504393
CCR2 antagonist
|
RS504393 is a potent, selective CCR2 antagonist with IC50 of 89 nM, shows no activity against CCR1. |
| PC-23668 |
CTCE-9908
CXCR4 antagonist
|
CTCE-9908 is a potent and selective CXCR4 antagonist, induces mitotic catastrophe in ovarian cancer cells. |
| PC-23312 |
DZH2
CCR5/CXCR4 inhibitor
|
DZH2 is a dual inhibitor of the chemokine receptors CCR5 and CXCR4 with IC50 of 8.7/13.7 uM in Ca2+-mobilization assays. |
