| Cat. No. |
Product Name |
Information |
| PC-23094 |
Lacutoclax
Bcl-2 inhibitor
|
Lacutoclax (LP-108) is a highly potent and selective inhibitor of BCL-2 with comparable or more potent in vitro inhibitory activity compared to venetoclax. |
| PC-23065 |
Bfl-1 inhibitor (R,R,S)-26
Bfl-1 inhibitor
|
Bfl-1 inhibitor (R,R,S)-26 is a potent, selective, covalent, cell active Bfl-1 inhibitor with IC50 of 22 nM, shows no activity against Bcl-xl, Bcl-2 and Mcl-1 (IC50>30 uM). |
| PC-22977 |
BRD-810
Mcl1 inhibitor
|
BRD-810 (BRD810) is a potent and selective MCL1 inhibitor with IC50 of 0.3 nM in AMO-1 cells, potently binds to the BH3 groove of MCL1 protein. |
| PC-22111 |
TUDCA
Bax inhibitor
|
Tauroursodeoxycholic acid (TUDCA) is a neuroprotective bile conjugate, prevents Bax translocation both in vitro and in vivo, thereby preserving mitochondrial function and suppressing apoptosis. |
| PC-22106 |
BAM7
Bax activator
|
BAM7 is a selective Bax activator, competes with FITC-BIM SAHB for BAX binding with IC50 of 3.3 uM, activates BAX and BAX-dependent cell death. |
| PC-22105 |
CBI1
Bax inhibitor
|
Covalent BAX inhibitor 1 (CBI1) is a specific, covalent BAX inhibitor selectively derivatizes BAX at Cys126 and inhibits BAX activation by triggering ligands or point mutagenesis. |
| PC-21675 |
Sonrotoclax
Bcl-2 inhibitor
|
Sonrotoclax (BGB-11417) is a potent, selective and second-generation BCL2 inhibitor with IC50 of 0.014 nM and SPR KD value of 0.046 nM, overcomes BCL2 G101V mutation-induced venetoclax resistance. |
| PC-21609 |
WK369
BCL6 inhibitor
|
WK369 (WK-369) is a specific small molecule inhibitor of BCL6, directly binds to the BCL6-BTB domain (SPR KD=2.24 uM) and blocks the interaction between BCL6 and SMRT with IC50 of 0.32 uM in HTRF assays. |
| PC-21258 |
M109S
Bax inhibitor
|
M109S is a small molecule protecting cells from mitochondria-dependent apoptosis wtih EC50 of 23.4 nM in iBax cells, directly interacts with Bax (Kd=153 nM, MST assay) and inhibits Bax activation. |
| PC-21117 |
PDCD2 ligand 7e
PDCD2 modulator
|
PDCD2 ligand 7e is a small molecule that may directly bind to programmed cell death 2 (PDCD2), rescues PDCD2 degradation induced by PDCD2 degrader 10e. |
| PC-21059 |
WK499
BCL6 inhibitor
|
WK499 (WK-499) is a small molecule inhibitor of BCL6 with IC50 of 11.7 nM in HTRF assay, directly binds to BCL6 BTB (SPR KD=148 nM), inhibits the BCL6-mediated transcriptional repression activity. |
| PC-20689 |
BAU-243
Bcl-2 inhibitor
|
BAU-243 (BAU243) is a novel BH3 mimetic Bcl-2 inhibitor with a high affinity, effectively reduces overall GBM cell proliferation including a subpopulation of cancer-initiating cells. |
