Z-Arg-Lys-AOMK | Cathepsin B inhibitor | Probechem Biochemicals

Chemical Structure : Z-Arg-Lys-AOMK

CAS No.: 2810056-57-4

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Z-Arg-Lys-AOMK (Cathepsin B inhibitor)

货号: PC-38309Not For Human Use, Lab Use Only.

Z-Arg-Lys-AOMK is a potent, selective, irreversible neutral pH 7.2 inhibitor of Cathepsin B with IC50 of 13 nM, >100-fold higher potent than at pH 4.6 (IC50=1,830 nM).

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2 mg	￥2880	In stock
5 mg	￥4580	In stock
10 mg	￥7280	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

Z-Arg-Lys-AOMK is a potent, selective, irreversible neutral pH 7.2 inhibitor of Cathepsin B with IC50 of 13 nM, >100-fold higher potent than at pH 4.6 (IC50=1,830 nM).
Z-Arg-Lys-AOMK displayed high specificity for cathepsin B compared to other lysosomal cysteine cathepsins.
Z-Arg-Lys-AOMK selectively inhibits cathepsin B cleavage of peptides at neutral cytosolic pH compared to acidic lysosomal pH conditions.
Z-Arg-Lys-AOMK completely inhibited cathepsin B in human neuroblastoma cell lysates at 1 uM.
Z-Arg-Lys-AOMK is cell permeable and inhibits intracellular cathepsin B.

物理化学性质&存储条件

分子量	582.702
分子式	C30H42N6O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-7-amino-3-((S)-2-(((benzyloxy)carbonyl)amino)-5-guanidinopentanamido)-2-oxoheptyl 2,6-dimethylbenzoate

参考文献

1. Michael C Yoon, et al. ACS Chem Biol. 2021 Sep 17;16(9):1628-1643.

Z-Arg-Lys-AOMK (Cathepsin B inhibitor)

生物&药学活性

物理化学性质&存储条件

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Z-Arg-Lys-AOMK (Cathepsin B inhibitor)

生物&药学活性

物理化学性质&存储条件

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