VBY-825 | Cathepsin S inhibitor | Probechem Biochemicals

Chemical Structure : VBY-825

CAS No.: 1310340-58-9

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VBY-825 (VBY825)

货号: PC-21763Not For Human Use, Lab Use Only.

VBY-825 is an reversible cathepsin inhibitor of cathepsins B, L, S and V.with Ki values of 130/250/250/330/2.3/4.7 nM (cathepsin S/L/ZV/Bhumanized-rabbit cathepsin K/cathepsin F).

规格	价格	库存
2 mg	￥3580	In stock
5 mg	￥5980	In stock
10 mg		Get quote
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

VBY-825 is an reversible cathepsin inhibitor of cathepsins B, L, S and V.with Ki values of 130/250/250/330/2.3/4.7 nM (cathepsin S/L/ZV/Bhumanized-rabbit cathepsin K/cathepsin F).
VBY-825 significantly decreases tumor burden and tumor number in pre-clinical model of pancreatic islet cancer.
VBY-825 antagonizes SARS coronavirus 2 (SARS-CoV-2) viral replication.

物理化学性质&存储条件

分子量	535.55
分子式	C23H29F4N3O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-Cyclopropyl-3-((R)-3-((cyclopropylmethyl)sulfonyl)-2-(((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl)amino)propanamido)-2-oxopentanamide

参考文献

1. Riva L, et al. bioRxiv. 2020 Apr 17:2020.04.16.044016.

2. Riva L, et al. Nature. 2020 Oct;586(7827):113-119.

3. Elie BT, et al. Biochimie. 2010 Nov;92(11):1618-24.

VBY-825 (VBY825)

生物&药学活性

物理化学性质&存储条件

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VBY-825 (VBY825)

生物&药学活性

物理化学性质&存储条件

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