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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Cathepsin-ONO-5334
ONO-5334

Chemical Structure : ONO-5334

CAS No.: 868273-90-9

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ONO-5334 (ONO5334, ONO 5334)

货号: PC-61421Not For Human Use, Lab Use Only.

ONO-5334 is a potent, selective, orally active inhibitor of cathepsin K (CTSK) with Ki of 0.1 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively.

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2 mg ￥2180 In stock
5 mg ￥3580 In stock
10 mg ￥5580 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ONO-5334 is a potent, selective, orally active inhibitor of cathepsin K (CTSK) with Ki of 0.1 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively.
ONO-5334 shows less or no potentcy for human cathepsin S/L/B/C (Ki=0.83/1.7/32/2500 nM).
ONO-5334  inhibits human osteoclasts bone resorption in vitro at a concentration more than 100 fold lower than that of alendronate.
ONO-5334  reduces plasma calcium level increased by PTHrP in thyroparathyroidectomized rats, decreases serum and urine C-telopeptide of type I collagen level.
ONO 5334 is an effective antiviral compound against SAR-COV-2 virus activity with EC50 of 500 nM.

物理化学性质&存储条件

分子量 438.59
分子式 C21H34N4O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-((S)-1-cyclohexyl-3-(2-((R,Z)-3,4-dimethylthiazolidin-2-ylidene)hydrazinyl)-2,3-dioxopropyl)cycloheptanecarboxamide

参考文献

1. Ochi Y, et al. Bone. 2011 Dec;49(6):1351-6.

2. Ochi Y, et al. Bone. 2014 Aug;65:1-8. doi: 10.1016/j.bone.2014.04.023.

3. Ochi Y, et al. J Bone Miner Metab. 2014 Nov;32(6):645-52.

4. Nagase S, et al. Br J Clin Pharmacol. 2012 Dec;74(6):959-70.

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