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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-iGluR-NAB-14
NAB-14

Chemical Structure : NAB-14

CAS No.: 1237541-73-9

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NAB-14 (NAB14)

货号: PC-63207Not For Human Use, Lab Use Only.

NAB-14 is a potent, selective negative allosteric modulator / antagonist of GluN2C/2D-containing NMDA receptors with IC50 of 580 nM, >800-fold selective over GluN2A/GluN2 receptors.

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5 mg ￥880 In stock
10 mg ￥1280 In stock
10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NAB-14 is a potent, selective negative allosteric modulator / antagonist of GluN2C/2D-containing NMDA receptors with IC50 of 580 nM, >800-fold selective over GluN2A/GluN2 receptors.
NAB-14 inhibits triheteromeric (GluN1/GluN2A/GluN2C) NMDARs with modestly reduced potency and efficacy compared to diheteromeric (GluN1/GluN2C/GluN2C) receptors.
NAB-14 inhibits GluN2D-mediated synaptic currents in rat subthalamic neurons and mouse hippocampal interneurons, but has no effect on synaptic transmission in hippocampal pyramidal neurons.

物理化学性质&存储条件

分子量 351.406
分子式 C20H21N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-((1H-indol-7-yl)carbamoyl)phenyl diethylcarbamate

参考文献

1. Swanger SA, et al. ACS Chem Neurosci. 2018 Feb 21;9(2):306-319.

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