K777 (K11777, S-001, SLV213)

Chemical Structure : K777

CAS No.: 233277-99-1

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货号: PC-73032Not For Human Use, Lab Use Only.

K777 (K11777, S-001, SLV213) is a highly potent, irreversible, covalent inhibitor of mammalian cathepsin L and other cysteine proteases of clan CA.

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

K777 (K11777, S-001, SLV213) is a highly potent, irreversible, covalent inhibitor of mammalian cathepsin L and other cysteine proteases of clan CA.
K777 was originally developed as an inhibitor of cathepsin S, but later showed promise as an antiparasitic agent.
K777 inhibits C. parvum growth in mammalian cell lines in a concentration-dependent manner, rescues mice from a lethal Cryptosporidium parvum infection
K777 blocked the entry of pseudovirus forms of SARS-CoV-1 and MERS into Vero E6 or HEK293 cells, likely due to inactivation of cathepsin L (CTSL) on cell surfaces and/or within endosomes.
K777 reduced SARS-CoV-2 viral infectivity in several host cells: Vero E6 (EC50< 74 nM), HeLa/ACE2 (4 nM), Caco-2 (EC90 = 4.3 μM), and A549/ACE2 (<80 nM).

物理化学性质&存储条件

分子量	574.74
分子式	C32H38N4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-methyl-N-((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)propan-2-yl)piperazine-1-carboxamide

参考文献

1. Mellott DM, et al. ACS Chem Biol. 2021 Apr 16;16(4):642-650.

2. J T Palmer, et al. J Med Chem. 1995 Aug 18;38(17):3193-6.

3. Ndao M, et al. Antimicrob Agents Chemother. 2013 Dec;57(12):6063-73.