Isomangiferin |CAS:24699-16-9 Probechem Biochemicals

Chemical Structure : Isomangiferin

CAS No.: 24699-16-9

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Isomangiferin

货号: PN-30006Not For Human Use, Lab Use Only.

Isomangiferin is the major tetracyclic oxindole alkaloid components of Uncaira species, inhibits NMDA receptor with IC50 of 43.2 uM, also blocks calcium channel.

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10 mg	￥3450	In stock
50 mg	￥6950	In stock
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生物&药学活性

Isomangiferin is the major tetracyclic oxindole alkaloid components of Uncaira species, inhibits NMDA receptor with IC50 of 43.2 uM, also blocks calcium channel; also effectively blocks the EphA4-dependent signaling in hippocampal neurons, reduces the EphA4 activity effectively in the hippocampus of APP/PS1 transgenic mice after oral administration, restores the impaired long-term potentiation in transgenic mouse models of AD.

物理化学性质&存储条件

分子量	422.3396
分子式	C19H18O11
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping	Room temperature in continental US; may vary elsewhere
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-beta-D-Glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one

参考文献

1. Kang TH, et al. Eur J Pharmacol. 2002 Nov 22;455(1):27-34.

2. Kang TH, et al. Life Sci. 2004 Dec 3;76(3):331-43.

3. Fu AK, et al. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9959-64.

Isomangiferin

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Isomangiferin

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