Pictilisib (GSC-0941) | PI3K inhibitor | Probechem Biochemicals

Chemical Structure : GDC-0941

CAS No.: 957054-30-7

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GDC-0941 (Pictilisib, GDC0941)

货号: PC-45820Not For Human Use, Lab Use Only.

Pictilisib (GSC-0941) is a potent, selective, orally bioavailable inhibitor of class I PI3Ks with IC50 of 3/33/3/75 nM for p110α/β/γ/δ, respectively.

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10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
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生物&药学活性

Pictilisib (GSC-0941) is a potent, selective, orally bioavailable inhibitor of class I PI3Ks with IC50 of 3/33/3/75 nM for p110α/β/γ/δ, respectively.
Pictilisib (GSC-0941) shows similar activity for mutant p110α E545K and H1047R (IC50=3 nM), weak or little activity for C2α, Vps34, DNA-PK, and mTOR (IC50>500 nM).
Pictilisib (GSC-0941) inhibits Akt (Ser473) phosphorylation in U87MG, PC3, and MDA-MB-361 cells with IC50s of 46, 37, and 28 nM, respectively, and respective GI50 is 0.95, 0.28, and 0.72 uM.
Pictilisib (GSC-0941) exhibits tumor growth inhibition in U87MG human glioblastoma xenografts.

物理化学性质&存储条件

分子量	513.6356
分子式	C23H27N7O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 29 mg/mL
Chemical Name/SMILES	Thieno[3,2-d]pyrimidine, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-

参考文献

1. Folkes AJ, et al. J Med Chem. 2008 Sep 25;51(18):5522-32.

2. Junttila TT, et al. Cancer Cell. 2009 May 5;15(5):429-40.

3. Raynaud FI, et al. Mol Cancer Ther. 2009 Jul;8(7):1725-38.

GDC-0941 (Pictilisib, GDC0941)

生物&药学活性

物理化学性质&存储条件

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GDC-0941 (Pictilisib, GDC0941)

生物&药学活性

物理化学性质&存储条件

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