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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Cathepsin-CA-074
CA-074

Chemical Structure : CA-074

CAS No.: 134448-10-5

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CA-074 (CA074)

货号: PC-21936Not For Human Use, Lab Use Only.

CA-074 is a potent, specific and cell-permeable inhibitor of cathepsin B with Ki of 2-5 nM.

规格 价格 库存 数量
5 mg ￥2180 In stock
10 mg ￥3580 In stock
25 mg ￥5880 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CA-074 is a potent, specific and cell-permeable inhibitor of cathepsin B with Ki of 2-5 nM.
CA-074 displays 10,000-30,000 times greater inhibitory activity than cathepsin H and L.
CA-074 improves memory and reduces beta-amyloid in transgenic Alzheimer disease mice.

物理化学性质&存储条件

分子量 383.45
分子式 C18H29N3O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-1-((2S,3S)-3-Methyl-2-((2S,3S)-3-(propylcarbamoyl)oxirane-2-carboxamido)pentanoyl)pyrrolidine-2-carboxylic acid

参考文献

1. Towatari T, et al. FEBS Lett. 1991 Mar 25;280(2):311-5.

2. Montaser M, et al. Biol Chem. 2002 Jul-Aug;383(7-8):1305-8.

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