Balicatib (AAE581)

Chemical Structure : Balicatib

CAS No.: 354813-19-7

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货号: PC-21937Not For Human Use, Lab Use Only.

Balicatib (AAE581) is a potent, selective and orally active and selective cathepsin K inhibitor with IC50 of 22 nM.

规格	价格	库存
5 mg	￥580	In stock
10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Balicatib (AAE581) is a potent, selective and orally active and selective cathepsin K inhibitor with IC50 of 22 nM.
Balicatib (AAE581) displays 10-100-fold more potent in cell-based enzyme occupancy assays than cathepsin B, L, and S.
Balicatib (AAE581) stimulates periosteal bone formation in monkeys.

物理化学性质&存储条件

分子量	411.55
分子式	C23H33N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-((cyanomethyl)carbamoyl)cyclohexyl)-4-(4-propylpiperazin-1-yl)benzamide

参考文献

1. Falgueyret JP, et al. J Med Chem. 2005 Dec 1;48(24):7535-43.

2. Jerome C, et al. Osteoporos Int. 2011 Dec;22(12):3001-11.