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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-JAK-BHV-8000
BHV-8000

Chemical Structure : BHV-8000

CAS No.: 2222137-86-0

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BHV-8000 (TLL-041)

货号: PC-24435Not For Human Use, Lab Use Only.

BHV-8000 (TLL-041) is a potent, highly selective, oral, brain-penetrant dual TYK2/JAK1 inhibitor.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

BHV-8000 (TLL-041) is a potent, highly selective, oral, brain-penetrant dual TYK2/JAK1 inhibitor.
BHV-8000 effectively blocks Th17 cell generation, Type I IFN signaling, and inflammation.

物理化学性质&存储条件

分子量 296.33
分子式 C16H16N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2R,5S)-Tetrahydro-5-(2-methyl-1H-furo[3,2-b]imidazo[4,5-d]pyridin-1-yl)-2H-pyran-2-acetonitrile

参考文献

1. Patent WO2018067422 A1.

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