Abbapolin 8

Chemical Structure : Abbapolin 8

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货号: PC-27575Not For Human Use, Lab Use Only.

Abbapolin 8 is a specific, non-peptidic inhibitor of PLK1 Polo-box domain (PBD), directly engages PLK1 in cells, induces selective degradation of endogenous PLK1.

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生物&药学活性

Abbapolin 8 is a specific, non-peptidic inhibitor of PLK1 Polo-box domain (PBD), directly engages PLK1 in cells, induces selective degradation of endogenous PLK1.
Abbapolin 8 potently engages PLK1 in cells as determined by an increase in PLK1 thermal stability at sub-micromolar doses, but not for PLK3.
Abbapolin 8 inhibits PC3 prostate cancer cells with IC50 of 3.41 uM in a 72-hour MTT assay.
Abbapolin 8 inhibits colony formation of PC3 cells with IC50 of 6.28 uM.
Abbapolin 8 causes PLK1 degradation with DC50 of 5.005 uM in PC3 cells (72 h).
Abbapolin 8 induces degradation of PLK1 protein in PC3 prostate cancer xenograft tumors, shows synergy effect in combination with enzalutamide.

物理化学性质&存储条件

分子量	368.48
分子式	C22H28N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(heptylamino)benzamido)-5-methylbenzoic acid

参考文献

1. Merhej G, et al. bioRxiv [Preprint]. 2026 Jul 24:2026.07.02.736204.

Abbapolin 8

生物&药学活性

物理化学性质&存储条件

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Abbapolin 8

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