| Cat. No. |
Product Name |
Information |
| PC-26042 |
Basimglurant
mGluR5 NAM
|
Basimglurant (RG7090) is a potent, selective and orally available mGlu5 receptor (mGluR5) negative allosteric modulator (NAM) with Kd of 1.1 nM. |
| PC-26041 |
MTEP
mGluR5 antagonist
|
MTEP is a potent, selective, non-competitive mGlu5 antagonist with IC50 of 5 nM and Ki of 16 nM. |
| PC-26040 |
MPEP hydrochloride
mGluR5 antagonist
|
MPEP hydrochloride is a potent, selective, noncompetitive, orally active and systemically active mGlu5 receptor (mGluR5) antagonist with IC50 of 36 nM, has anxiolytic-or antidepressant-like effects. |
| PC-26039 |
MPEP
mGluR5 antagonist
|
MPEP is a potent, selective, noncompetitive, orally active and systemically active mGlu5 receptor (mGluR5) antagonist with IC50 of 36 nM, has anxiolytic-or antidepressant-like effects. |
| PC-26037 |
VU6035386
mGluR5 NAM
|
VU6035386 is a potent, selective negative allosteric modulator (NAM) of metabotropic glutamate receptor subtype 5 (mGlu5, mGluR5) with IC50 of 64 nM. |
| PC-24064 |
VU6033685
mGlu1 PAM
|
VU6033685 (BI1752) is a potent, selective positive allosteric modulator (PAM) of metabotropic glutamate receptor subtype 1 (mGlu1) with EC50 of 39 nM, Emax=65% (human mGlu1), and EC50 of 107 nM, Emax=94%. |
| PC-23781 |
VU6004909
mGlu1 PAM
|
VU6004909 is a selective, CNS penetrant metabotropic glutamate receptor subtype 1 (mGlu1) positive allosteric modulator (PAM) with EC50 of 25.7 nM and 31 nM for human and rat mGlu1 respectively. |
| PC-23780 |
LY367385
mGluR1 antagonist
|
LY367385 is a potent, highly selective mGluR1 antagonis with IC50 of 8.8 μM for inhibiting of quisqualate-induced phosphoinositide (PI) hydrolysis, shows no activity against mGluR5. |
| PC-23779 |
VU0486321
mGlu1 PAM
|
VU0486321 is a potent, selective metabotropic glutamate receptor subtype 1 (mGlu1, mGluR1) positive allosteric modulator (PAM) with EC50 of 31.87 nM (human Glu1), 35-fold selective over mGlu4. |
| PC-23778 |
VU0483605
mGlu1 PAM
|
VU0483605 is a potent, selective positive allosteric modulator (PAM) of mGluR1 with EC50 of 350 nM. |
| PC-23777 |
VU6024578
mGlu1 PAM
|
VU6024578 (BI02982816) is a selective and CNS penetrant metabotropic glutamate receptor subtype 1 (mGlu1) positive allosteric modulator (PAM) with EC50 of 54 nM and 46 nM for human and rat mGlu1 respectively. |
| PC-22952 |
FO-4-15
mGluR1 activator
|
FO-4-15 is a small molecule taregting mGluR1 with low cytotoxicity and anti-H2O2 effect, significantly reduces Aβ accumulation, Tau hyper-phosphorylation, and synaptic impairments in 3×Tg mice, activates mGluR1/CaMKIIα pathway. |
