| Cat. No. |
Product Name |
Information |
| PC-72171 |
K-975
TEAD inhibitor
|
K-975 (K975, YAP1-TEAD inhibitor K975) is a potent, specific inhibitor of YAP1/TAZ-TEAD signaling, inhibits YAP1/TAZ-TEAD protein-protein interaction, a pan-TEAD inhibitor binds to Cys359 of TEAD1-YBD. |
| PC-38304 |
YAP activator PY-60
YAP activator
|
YAP activator PY-60 (PY-60) is a novel small molecule activator of YAP transcriptional activity (EC50=1.5 uM) via targeting annexin A2 (ANXA2). |
| PC-38143 |
TEAD-IN-2
TEAD antagonist
|
TEAD-IN-2 (TEAD antagonist 2) is a small molecule TEAD antagonist (TEAD2 IC50=603 nM FP assays, SPR Kd=229 nM) that binds the TEAD lipid pocket and disrupts TEAD S-palmitoylation. |
| PC-36118 |
Verteporfin
YAP inhibitor
|
Verteporfin (CL 318952, BPD-MA) is a benzoporphyrin derivative that inhibits Yap via disruption of YAP-TEAD interactions, Verteporfin is a clinically used photosensitizer. |
| PC-36034 |
IBS003031
YAP1 activator
|
IBS003031 (IBS-003031) is a novel chemical Yes-associated protein 1 (YAP1) activator, up-regulates H2B-mCherry expression at 1 and 3 uM in mCherry signal based reporter assays. |
| PC-35898 |
TED-347
YAP-TEAD4 inhibitor
|
TED-347 (TED347) is an irreversible inhibitor of TEAD4-Yap1 protein-protein interaction (EC50=5.9 uM in FP asssays) via covalent modification of conserved cysteine (Cys367, Ki=1.3 uM), inhibits its binding to Yap1, blocked its transcriptional activity. |
| PC-35820 |
TT-10
YAP-TEAD activator
|
TT-10 (YAP-TEAD activator TT-10) is a small molecule activator that activates pro-proliferative YES-associated protein (YAP) and transcriptional enhancer factor domain (TEAD) activities in cardiomyocytes. |
| PC-60375 |
YAP1 inhibitor CA3
YAP1 inhibitor, Ferroptosis inducer
|
YAP1 inhibitor CA3 (CA3, CIL56) is a small molecule that has remarkable inhibitory activity on YAP1/TEAD transcriptional activity |
| PC-24521 |
TJ-M11
YAP/TAZ inhibitor
|
TJ-M11 is a synthesized peptide inhibitor of YAP/TAZ transactivation domain (TAD), specifically blocks YAP transactivation (IC50=5.96 uM, NCI-H1299 cells) by disrupting its TAD interactions with the cofactors MED15 and TAF4. |
| PC-24392 |
GL-V9
YAP1 inhibitor
|
GL-V9 is synthetic flavonoid derivative that possess an antitumor effect, effectively promotes the degradation of YAP1, reduces YAP1 nuclear localization, and induces mitochondrial apoptosis in PDAC cells, also induce apoptosis of CML cells via MAPK signaling pathway. |
| PC-23994 |
BPI-460372
TEAD inhibitor
|
BPI-460372 is a potent, orally available, covalent, irreversible inhibitor of TEAD1/3/4, irreversibly binds to the cysteine residue in the TEAD palmitoylation pocket, preventing TEAD palmitoylation and inhibiting its biological function. |
| PC-23670 |
M3686
TEAD1 inhibitor
|
M3686 is a potent, selective TEAD1 inhibitor with IC50 of 51 nM in TEAD reporter assay, shows weaker binding to TEAD3, and negligible activity on TEAD2 and TEAD4. |
