| Cat. No. |
Product Name |
Information |
| PC-73282 |
DC-TEADin1072
TEAD1/3 inhibitor
|
DC-TEADin1072 is a novel TEAD1/3 covalent inhibitor with biochemical IC50 values of 0.61 and 0.58 uM against TEAD1 and TEAD3, respectively. |
| PC-73155 |
MYF-01-37
TEAD covalent inhibitor
|
MYF-01-37 (MYF-1-37) is a novel covalent TEAD inhibitor targeting Cys380, binds to palmitoylation pocket in TEAD1, targets YAP dependency upon combined EGFR/MEK inhibition. |
| PC-72508 |
VT104
pan-TEAD inhibitor
|
VT104 (VT-104) is a specific small molecule inhibitor of YAP/TAZ-TEAD-dependent transcription with IC50 of 10.4 nM in YAP reporter assay, pan-TEAD palmitoylation inhibitor. |
| PC-72507 |
VT107
pan-TEAD inhibitor
|
VT107 (VT-107) is a specific small molecule inhibitor of YAP/TAZ-TEAD-dependent transcription with IC50 of 4.93 nM in YAP reporter assay, pan-TEAD palmitoylation inhibitor. |
| PC-72506 |
VT103
TEAD1 inhibitor
|
VT103 (VT-103) is a specific small molecule inhibitor of YAP/TAZ-TEAD-dependent transcription with IC50 of 1.2 nM in YAP reporter assay, selectively blocks TEAD1 auto-palmitoylation. |
| PC-72427 |
LM98
YAP-TEAD inhibitor
|
LM98 (TEAD inhibitor LM98) is a flufenamic acid analogue, shows strong affinity to TEAD, inhibits its autopalmitoylation and reduces the YAP-TEAD transcriptional activity. |
| PC-72171 |
K-975
YAP-TEAD inhibitor
|
K-975 (K975, YAP1-TEAD inhibitor K975) is a potent, specific inhibitor of YAP1/TAZ-TEAD signaling, inhibits YAP1/TAZ-TEAD protein-protein interaction, a pan-TEAD inhibitor binds to Cys359 of TEAD1-YBD. |
| PC-38304 |
Annexin A2 inhibitor PY-60
ANXA2 inhibitor, YAP activator
|
Annexin A2 inhibitor PY-60 (PY-60) is a novel small molecule activator of YAP transcriptional activity (EC50=1.5 uM) via targeting annexin A2 (ANXA2). |
| PC-38143 |
TEAD inhibitor Compound 2
TEAD antagonist
|
TEAD inhibitor Compound 2 (TEAD-IN-2) is a small molecule TEAD antagonist (TEAD2 IC50=603 nM FP assays, SPR Kd=229 nM) that binds the TEAD lipid pocket and disrupts TEAD S-palmitoylation. |
| PC-36118 |
Verteporfin
YAP inhibitor
|
Verteporfin (CL 318952, BPD-MA) is a benzoporphyrin derivative that inhibits Yap via disruption of YAP-TEAD interactions, Verteporfin is a clinically used photosensitizer. |
| PC-36034 |
IBS003031
YAP1 activator
|
IBS003031 (IBS-003031) is a novel chemical Yes-associated protein 1 (YAP1) activator, up-regulates H2B-mCherry expression at 1 and 3 uM in mCherry signal based reporter assays. |
| PC-35898 |
TED-347
YAP-TEAD4 inhibitor
|
TED-347 (TED347) is an irreversible inhibitor of TEAD4-Yap1 protein-protein interaction (EC50=5.9 uM in FP asssays) via covalent modification of conserved cysteine (Cys367, Ki=1.3 uM), inhibits its binding to Yap1, blocked its transcriptional activity. |
