| Cat. No. |
Product Name |
Information |
| PC-72304 |
GNE-1858
HPK1/MAP4K1 inhibitor
|
GNE-1858 (GNE1858) is a potent, selective, ATP-competitive inhibitor of HPK1 (MAP4K1) with IC50 of 1.9 nM in the SLP76 phosphorylation assay. |
| PC-72303 |
A-745
HPK1/MAP4K1 inhibitor
|
A-745 (A745) is a selective and potent HPK1 chemical probe (inhibitor) of HPK1 (MAP4K1) with IC50 of 4 nM. |
| PC-72055 |
HPK1 inhibitor CompK
HPK1/MAP4K1 inhibitor
|
Compound K (HPK1 inhibitor CompK) is a novel, potent, highly selective HPK1 (MAP4K1) kinase inhibitor with IC50 of 2.6 nM, 50-fold selectivity against other members of the MAP4K family. |
| PC-72013 |
HPK1 inhibitor 1
HPK1/MAP4K1 inhibitor
|
HPK1 inhibitor 1 is a highly potent, selective inhibitor of HPK1/MAP4K1 with biochemical IC50 of 0.0465 nM. |
| PC-36139 |
DMX-5804
MAP4K4 inhibitor
|
DMX-5804 (DMX5804) is a potent, selective small-molecule inhibitor of MAP4K4 with IC50 of 3 nM. |
| PC-35005 |
MAP4K4-IN-37
MAP4K4 inhibitor
|
MAP4K4-IN-37 (PF-06745013) is a potent, selective, orally active inhibitor of serine-threonine kinase MAP4K4 with IC50 of 0.4 nM. |
| PC-42954 |
HG6-64-1
TAK1/MAP4K2 inhibitor
|
HG6-64-1 is a potent dual TAK1 and MAP4K2 ((germinal center kinase, GCK)) inhibitor with IC50 of 41 nM and 98 nM, respectively. |
| PC-62937 |
MAP4K4-IN-44
MAP4K4 inhibitor
|
MAP4K4-IN-44 is a potent, moderately selective small molecule MAP4K4 inhibitor with IC50 of 5 nM in LC3K assay, demonstrates favorable in vivo bioavailability in mouse. |
| PC-62936 |
GNE-220
MAP4K4 inhibitor
|
GNE-220 is a potent and selective inhibitor of MAP4K4 with IC50 of 7 nM, also inhibits MINK (MAP4K6), DMPK and KHS1 (MAP4K5) with IC50 of 9 nM, 476 nM and 1,110 nM. |
| PC-62935 |
MAP4K4-IN-17
MAP4K4 inhibitor
|
MAP4K4-IN-17 is a potent and highly selective MAP4K4 inhibitor with IC50 of 14.9 nM, showes improved overall drug-like properties compared to PF-06260933. |
| PC-61694 |
PF-06260933 dihydrochloride
MAP4K4 inhibitor
|
PF-06260933 dihydrochloride is a potent, selective and orally bioavailable MAP4K4 inhibitor with kinase IC50 of 3.7 nM, cell IC50 of 160 nM. |
| PC-61165 |
MAP4K4-IN-11e
MAP4K4 inhibitor
|
MAP4K4-IN-11e is a potent, selective, ATP-competitive inhibitor of MAP4K4 with IC50 of 1.9 uM, without effect on other stress pathway related kinases. |
