| Cat. No. |
Product Name |
Information |
| PC-38431 |
Zectivimod
S1P receptor agonist
|
Zectivimod is a sphingosine-1-phosphate (S1P) receptor agonist. |
| PC-38427 |
Vibozilimod
S1PR1 agonist
|
Vibozilimod (SCD 044) is an orally-available, potent, selective sphingosine-1-phosphate receptor-1 (S1PR1) agonist with EC50 of 0.2 nM. |
| PC-73203 |
ML248
S1P4 agonist
|
ML248 (CYM50308) is a potent and selective S1P4 receptor agonist with EC50 of 37.7 nM-79.1 nM. |
| PC-73187 |
S1P5-IN-15
S1P5 antagonist
|
S1P5-IN-15 is a potent, selective, orally active and brain-penetrant S1P5 antagonist with IC50 of 0.1 nM, no effect on S1P1-4. |
| PC-72841 |
ALESIA
S1PR3 agonist
|
ALESIA is a specific sphingosine-1-phosphate receptor 3 (S1PR3)-G12-biased agonist and selectively induces G12 signal. |
| PC-72368 |
SAR247799
S1P1 agonist
|
SAR247799 is a potent, selective G protein-biased S1P1 agonist with EC50 of 39 and 19 nM in β-arrestin and internalization assays, respectivey. |
| PC-72349 |
Admilparant
LPA1 antagonist
|
Admilparant (BMS-986278) is a potent, selective lysophosphatidic acid receptor 1 (LPA1, LPAR1) antagonist with Kb of 6.9 nM and 4.0 nM for human and mouse LPA1, respectively. |
| PC-35275 |
SAR-100842
LPA1 antagonist
|
Fipaxalparant (SAR100842) is a potent, selective, orally available antagonist of the Lysophosphatidic Acid 1 Receptor (LPA1 receptor) with IC50 of 31 nM in β-arrestin assays. |
| PC-35273 |
TAK-615
LPA1 antagonist
|
TAK-615 (TAK615) is a potent, selective, negative allosteric modulator (NAM) of the LPA1 receptor, partially inhibits the LPA response with IC50 of 91 nM (60% at 10 uM) in calcium mobilisation assays.. |
| PC-35245 |
BMS-986166
S1PR1 agonist
|
Udifitimod (BMS-986166) is a potent, selective sphingosine-1-phosphate receptor 1 (S1PR1) agonist for the treatment of ulcerative colitis. |
| PC-35197 |
ASP6432
LPA1 antagonist
|
ASP6432 (ASP-6432) is a potent and selective antagonist of LPA1 receptor, does-dependently inhibits LPA-stimulated increase in intracellular calcium ion with IC50 of 11 nM. |
| PC-43463 |
Ki16425
LPA1/LPA3 antagonist
|
Ki16425 (Debio 0719) is a potent, subtype-selective, competitive antagonist of lysophosphatidic acid receptor LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, shows no activity at LPA4, LPA5, LPA6. |
