| Cat. No. |
Product Name |
Information |
| PC-25591 |
NSC135618
Flavivirus NS2B-NS3 inhibitor
|
NSC135618 is a potent, allosteric inhibitor of the flavivirus NS2B-NS3 protease, inhibits the protease of Dengue virus 2 (DENV2) in vitro with IC50 of 1.8 uM, shows broad spectrum flavivirus protease, inhibits DENV2, Zika virus (ZIKV), West Nile virus (WNV), and Yellow fever virus (YFV) on A549 cells in vivo with EC50 in low micromolar range. |
| PC-24464 |
HeE1-2Tyr
Flavivirus RdRp inhibitor
|
HeE1-2Tyr is a potent, nonnucleoside inhibitor of flavivirus RNA dependent RNA polymerase (RdRp) with IC50 of 1.5 uM and 3.4 uM for DENV3 and WNV RdRps, respectively, also is a SARS-CoV-2 RdRp with IC50 of 27.6 uM. |
| PC-23620 |
Compound 3.47
EBOV inhibitor
|
Compound 3.47 is a small molecule antifilovirus compound, inhibits EboV infection by interfering with binding of cleaved virus glycoprotein (GP) to endosomal membrane protein Niemann-Pick C1 (NPC1). |
| PC-23619 |
EBOV inhibitor Compound 7
EBOV inhibitor
|
EBOV inhibitor Compound 7 is a a small-molecule entry inhibitor of filoviruses, inhibits infectious EBOV and Marburg virus (MARV) in cell-based assays with IC50 of 10 μM and 12 μM, respectively. |
| PC-23617 |
CBS1129
Filovirus inhibitor
|
CBS1129 is a small molecule inhibitor of filovirus entry, shows potent inhibitory activity against entry of both Ebola and Marburg viruses in human cancer cell lines (EC50=2.4 uM, pseudovirus (HIV/EBOV) assay). |
| PC-23615 |
VUN65671
EBOV/MARV inhibitor
|
VUN65671 is a potent small molecule inhibitor of Ebola (EBOV) and Marburg (MARV) virus entry with EC50 of 0.31 uM and 0.82 uM. |
| PC-23175 |
Methylene Blue
DENV NS2B-NS3 inhibitor
|
Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor, also is a Tau aggregation inhibitor, inhibits DENV NS2B-NS3 inhibitor (IC50=9 µM) and DENV infection in cells in the submicromolar range (EC50=0.36 µM). |
| PC-23174 |
Temoporfin
NS2B-NS3 inhibitor
|
Temoporfin (m-THPC) is a reduced porphyrin and potent second-generation photosensitizer, also is a potent flavivirus NS2B-NS3 interaction inhibitor with broad-spectrum antiviral activity. |
| PC-23173 |
NK-189
NS2B-NS3 inhibitor
|
NK-189 is a potent, specific flaviviral serine protease NS2B-NS3 inhibitor with submicromolar activities in viral replication assays (EC50=0.89 μM, DENV-2). |
| PC-23172 |
DENV NS2B-NS3 inhibitor 71
NS2B-NS3 inhibitor
|
DENV NS2B-NS3 inhibitor 71 is a potent, specific flaviviral serine protease NS2B-NS3 inhibitor with submicromolar activities in viral replication assays (EC50=0.24 μM, DENV-2). |
| PC-23171 |
NSC157058
NS2B-NS3 inhibitor
|
NSC157058 is a potent, allosteric inhibitor of ZIKV NS2B-NS3 protease with IC50 of 0.82 uM. |
| PC-23170 |
SYC-1307
NS2B-NS3 inhibitor
|
SYC-1307 is a potent, allosteric inhibitor of flavivirus NS2B-NS3 protease with IC50 of 0.2, 0.59, 0.59 and 0.78 uM for ZIKV, DENV2, DENV3 and WNV NS2B-NS3 respectively, shows submicromolar anti-orthoflaviviral efficacy in cells (EC50=0.3-0.6 uM). |
