| Cat. No. |
Product Name |
Information |
| PC-23010 |
Salinomycin
Ferroptosis inducer
|
Salinomycin is a polyether ionophore antibacterial agent that shows effects on mitochondrial ion translocation and respiration, inhibits Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation and induces ferroptosis in cancer cells. |
| PC-22833 |
NCOA4-FTH1 inhibitor 9a
NCOA4-FTH1 inhibitor
|
NCOA4-FTH1 inhibitor 9a is a new ferroptosis inhibitor through disrupting the NCOA4-FTH1 protein-protein interaction, reduces intracellular ferrous iron, inhibits Erastin-induced ferroptosiswith EC50 of 0.29 μM in HT22 cells. |
| PC-22475 |
BCP-T.A
Ferroptosis inducer
|
BCP-T.A is a potent ferroptosis inducer by binding to GPX4 with IC50 of 17 nM in ferroptosis sensitive cell line NCI-H522. |
| PC-22423 |
Erastin
Ferroptosis inducer
|
Erastin is a specific ferroptosis-inducing compound, shows RAS-selective lethality, also targetsvoltage-dependent anion channel 3 (VDAC3). |
| PC-21713 |
GPX4 inhibitor A16
GPX4 inhibitor
|
GPX4 inhibitor A16 is a potent, selective and covalent inhibitor of glutathione peroxidase 4 (GPX4), shows potent anti-proliferation activity the pancreatic cancer cell line AsPC-1 with IC50 of 22 nM. |
| PC-20924 |
FerroLOXIN-2
Ferroptosis inhibitor
|
FerroLOXIN-2 is a specific, small-molecule inhibitor of ferroptosis, inhibits 15LOX/PEBP1 catalytic complex rather than 15LOX alone, effectively suppresses ferroptosis in vitro and in vivo. |
| PC-20923 |
FerroLOXIN-1
Ferroptosis inhibitor
|
FerroLOXIN-1 is a specific, small-molecule inhibitor of ferroptosis, inhibits 15LOX/PEBP1 catalytic complex rather than 15LOX alone, effectively suppresses ferroptosis in vitro and in vivo. |
| PC-20810 |
AKI-02
Ferroptosis inhibitor
|
AKI-02 is a hydroxypyridinone-based iron chelator, potently inhibits labile iron-mediated ferroptosis. |
