FLT3 (inhibitors, antagonists, agonists)-ProbeChem.com

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Cat. No.	Product Name	Information
PC-27426	Faldoritinib FLT3 inhibitor	Faldoritinib is a potent, selective FLT3 inhibitor.
PC-26900	FYJ-195 FLT3 inhibitor	FYJ-195 is a highly potent type II FLT3 inhibitor with IC50 of 2.03 nM for FLT3-ITD, overcomes recalcitrant gatekeeper F691L and activation loop D835V/Y variants.
PC-26471	FLC-8 FLT3 inhibitor	FLC-8 is a potent, selective and covalent FLT3 inhibitor with IC50 of 10.2 nM, 11.6 nM and 24.1 nM for FLT3-WT, FLT3 G697R and FLT3 N676D respectively.
PC-26046	AMG 925 CDK4/FLT3 inhibitor	AMG 925 (AMG925, AMG-925) is a potent and orally bioavailable dual inhibitor of CDK4 and FLT3 with IC50 of 3 nM and 1 nM for CDK4/Cyclin D1 and FLT3 respectively.
PC-25800	FN-1501 FLT3 inhibitor	FN-1501 (FN1501) is a potent FLT3 and CDK inhibitor with IC50 of 0.27 nM, 2.47 nM, 0.85 nM and 1.96 nM for FLT3, CDK2/cyclin A, CDK4/cyclin D1, and CDK6/cyclin D1 respectively, induces collapsin response mediator protein 2 (CRMP2) dephosphorylation in breast cancer cells.
PC-25422	PLM-101 hydrochloride FLT3/RET inhibitor	PLM-101 hydrochloride is a synthetic derivative of indirubin and potent, dual FLT3/RET inhibitor with IC50 of 0.565 nM and 0.849 nM for FLT3-ITD and RET kinase respectively.
PC-25421	PLM-101 FLT3/RET inhibitor	PLM-101 is a synthetic derivative of indirubin and potent, dual FLT3/RET inhibitor with IC50 of 0.565 nM and 0.849 nM for FLT3-ITD and RET kinase respectively. PLM-101 inhibits the proliferation of Ba/F3 cells expressing FLT3-ITD-mutant kinases at the nanomolar (nM) concentration levels.
PC-24959	CCT241736 FLT3/Aurora kinase inhibitor	CCT241736 (Mobinitinib) is a potent, orally bioavailable dual FLT3/Aurora kinase inhibitor with binding Kd of 7.5/48/6.2/38/14 nM for Aurora-A/Aurora-B/FLT3 WT/FLT3-ITD/FLT3(D835Y) respectively.
PC-24406	Clifutinib besylate FLT3-ITD inhibitor	Clifutinib besylate (HEC73543) is potent, selective FLT3-ITD (internal tandem duplication mutations of FLT3) inhibitor with biochemical IC50 of 15.1 nM, exhibits significant antiproliferative activity against Ba/F3-FLT3-ITD cells with IC50 of 0.9 nM.
PC-23629	Danatinib FLT3 inhibitor	Danatinib is a potent and selective FLT3 inhibitor with IC50 of 3 nM, overcomes acquired resistance and shows effective inhibition against FLT3-ITD and/or FLT3-TKD mutations.
PC-21367	FLT3 inhibitor 17 FLT3 inhibitor	FLT3 inhibitor 17 is a potent, highly selective FLT3 inhibitor with IC50 of 1.2 nM and 1.4 nM for FLT3 WT and FLT3-D835Y, shows low activity against VEGFR, FGFR, PDGFR, c-KIT, and RET.

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