β2AR-IN-15 |CAS:2088234-50-6 Probechem Biochemicals

Chemical Structure : β2AR-IN-15

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β2AR-IN-15

货号: PC-70285Not For Human Use, Lab Use Only.

An allosteric, small-molecule negative modulator for β2AR with Kd of 1.7 uM.

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生物&药学活性

An allosteric, small-molecule negative modulator for β2AR with Kd of 1.7 uM; binds in proximity to the G-protein binding site on the cytosolic surface of the β2AR; inhibits cAMP production through the β2AR, but not that mediated by other Gs-coupled receptors; also similarly inhibits β-arrestin recruitment to the activated β2AR.

物理化学性质&存储条件

分子量	647.614
分子式	C34H39BrN4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((2S)-3-(((S)-3-(3-bromophenyl)-1-(methylamino)-1-oxopropan-2-yl)amino)-2-(2-cyclohexyl-2-phenylacetamido)-3-oxopropyl)benzamide

参考文献

1. Ahn S, et al. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1708-1713.

β2AR-IN-15

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β2AR-IN-15

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物理化学性质&存储条件

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