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首页-小分子抑制剂&激动剂-Others-Other Targets-α-difluoromethylornithine
α-difluoromethylornithine

Chemical Structure : α-difluoromethylornithine

CAS No.: 70052-12-9

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α-difluoromethylornithine (DFMO, Eflornithine, MDL71782)

货号: PC-25556Not For Human Use, Lab Use Only.

α-difluoromethylornithine (DFMO, Eflornithine, MDL71782) is a specific, irreversible inhibitor of polyamine biosynthesis enzyme Ornithine decarboxylase (ODC) with biochemicals IC50 of 252 uM, binding competitively with ornithine.

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100 mg ￥380 In stock
500 mg ￥880 In stock
1 g ￥1280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

α-difluoromethylornithine (DFMO, Eflornithine, MDL71782) is a specific, irreversible inhibitor of polyamine biosynthesis enzyme Ornithine decarboxylase (ODC) with biochemicals IC50 of 252 uM, binding competitively with ornithine.

物理化学性质&存储条件

分子量 182.17
分子式 C6H12F2N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,5-Diamino-2-(difluoromethyl)pentanoic acid

参考文献

1. Schultz CR, et al. J Med Chem. 2025 Mar 13;68(5):5760-5773.

2. Lipke DW, et al. Clin Exp Hypertens. 1997 Apr;19(3):297-312.

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