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首页-小分子抑制剂&激动剂-Others-Other Targets-α-Fluoromethylhistidine dihydrochloride
α-Fluoromethylhistidine dihydrochloride

Chemical Structure : α-Fluoromethylhistidine dihydrochloride

CAS No.: 81839-27-2

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α-Fluoromethylhistidine dihydrochloride (α-FMH dihydrochloride, alpha-Fluoromethylhistidine)

货号: PC-28396Not For Human Use, Lab Use Only.

alpha-fluoromethylhistidine (α-FMH) is an orally active, irreversible histamine producing enzyme histidine decarboxylase (HDC) inhibitor with IC50 of 1-2 uM for soluble histidine decarboxylase preparations, inhibits histamine synthesis with IC50 of 0.2 uM in intact cell suspensions.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

alpha-fluoromethylhistidine (α-FMH) is an orally active, irreversible histamine producing enzyme histidine decarboxylase (HDC) inhibitor with IC50 of 1-2 uM for soluble histidine decarboxylase preparations, inhibits histamine synthesis with IC50 of 0.2 uM in intact cell suspensions.

物理化学性质&存储条件

分子量 260.09
分子式 C7H12Cl2FN3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-2-((1H-Imidazol-4-yl)methyl)-2-amino-3-fluoropropanoic acid dihydrochloride

参考文献

1. WoldeMussie E, et al. Mol Pharmacol. 1985 Aug;28(2):191-9.

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