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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-ztz240
ztz240

Chemical Structure : ztz240

CAS No.: 325457-98-5

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ztz240 (ztz-240)

货号: PC-26104Not For Human Use, Lab Use Only.

ztz240 is a potent, selective activator of KCNQ2 potassium channel (Kv7.2) with EC50 of 5.8 uM on outward current of KCNQ2 channels.

规格 价格 库存 数量
5 mg ￥2580 In stock
10 mg ￥3980 In stock
25 mg ￥5980 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ztz240 is a potent, selective activator of KCNQ2 potassium channel (Kv7.2) with EC50 of 5.8 uM on outward current of KCNQ2 channels.
ztz240 binds to the open-state voltage-sensor domain (VSD).
ztz240 exhibits significant anti-epilepsy activity on mouse PTZ-induced seizure model.

物理化学性质&存储条件

分子量 250.66
分子式 C12H8ClFN2O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(6-chloro-pyridin-3-yl)-4-fluorobenzamide

参考文献

1. Li P, et al. Cell Res. 2013 Sep;23(9):1106-18.

2. Li X, et al. Cell Res. 2021 Jan;31(1):52-61.

3. Zhaobing Gao, et al. J Biol Chem. 2010 Sep 3;285(36):28322-32.

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