p97 inhibitor PPA | VCP/p97 inhibitor | Probechem Biochemicals

Chemical Structure : p97 inhibitor PPA

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p97 inhibitor PPA (VCP inhibitor PPA, ACJI-99C)

货号: PC-26297Not For Human Use, Lab Use Only.

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250 mg		Get quote

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生物&药学活性

p97 inhibitor PPA (ACJI-99C) is a selective, covalent p97/VCP ATPase inhibitor with IC50 of 0.6 uM in in vitro ATPase activity assay, with no activity against yeast Cdc48, and N-ethylmaleimide sensitive factor (NSF).
PPA inhibits proliferation of HCT116, HeLa, and RPMI8226 with IC50 of 2.7 μM, 6.1 μM, and 3.4 μM, respectively.
PPA inhibits proliferation of two HCT116 cell lines that are resistant to CB-5083 and NMS-873, respectively.
PPA covalently modifies VCP on the active site Cys522.

物理化学性质&存储条件

分子量	321.38
分子式	C18H19N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Propenamide, N-[1-(1,1-dimethylethyl)-3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-

参考文献

1. Gang Zhang, et al. Eur J Med Chem. 2021 Mar 5:213:113148.

p97 inhibitor PPA (VCP inhibitor PPA, ACJI-99C)

生物&药学活性

物理化学性质&存储条件

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p97 inhibitor PPA (VCP inhibitor PPA, ACJI-99C)

生物&药学活性

物理化学性质&存储条件

参考文献

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