p53 Y220C activator KG13 | p53 Y220C reactivator | Probechem Biochemicals

Chemical Structure : p53 Y220C activator KG13

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p53 Y220C activator KG13 (p53 Y220C reactivator)

货号: PC-25659Not For Human Use, Lab Use Only.

p53 Y220C activator KG13 is a allele-specific covalent small molecule that selectively reacts with the mutant cysteine Y220C of p53 (p53 Y220C), rescues wild-type thermal stability and gene activation.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

p53 Y220C activator KG13 is a allele-specific covalent small molecule that selectively reacts with the mutant cysteine Y220C of p53 (p53 Y220C), rescues wild-type thermal stability and gene activation.
KG13 stabilized cellular p53 Y220C and activated target gene expression.
KG13 could generate p53 WT activity specifically in tumor cells harboring the p53 Y220C mutation.

物理化学性质&存储条件

分子量	345.45
分子式	C22H23N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-methyl-1-(3-methyl-4-(2-methyl-1,2,3,4-tetrahydroisoquinolin-6-yl)-1H-pyrrolo[2,3-c]pyridin-1-yl)prop-2-en-1-one

参考文献

1. Guiley KZ, et al. Cancer Discov. 2023 Jan 9;13(1):56-69.

2. Patent WO2025151449 A1.