iCRT3 | β-catenin inhibitor | Probechem Biochemicals

Chemical Structure : iCRT3

CAS No.: 901751-47-1

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iCRT3 (iCRT-3)

货号: PC-62166Not For Human Use, Lab Use Only.

iCRT-3 is a selective, cell-permeable β-catenin responsive transcription (CRT) inhibitor with IC50 of 8.2 nM.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

iCRT3 is a selective, cell-permeable β-catenin responsive transcription (CRT) inhibitor with IC50 of 8.2 nM.
iCRT3 interferes with β-cat-TCF4 interaction via direct β-catenin (β-cat) binding, inhibits cellular expression of CRT target genes, including WISP1, AXN2, and CYCD1, in a dose-dependent manner (25-75 uM).
iCRT3 selectively inhibits the proliferation of HCT116 (75 µM), HT29 (75 µM), and several primary human colon cancer cultures (6.25-100 µg/ml).

物理化学性质&存储条件

分子量	394.53
分子式	C23H26N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)acetamide

参考文献

1. Lee E, et al. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15710-5.

2. Gonsalves FC, et al. Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):5954-63.

iCRT3 (iCRT-3)

生物&药学活性

物理化学性质&存储条件

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iCRT3 (iCRT-3)

生物&药学活性

物理化学性质&存储条件

参考文献

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