iCDM-34 | AhR agonist | Probechem Biochemicals

Chemical Structure : iCDM-34

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iCDM-34 (iCDM34)

货号: PC-21584Not For Human Use, Lab Use Only.

iCDM-34 is a small molecule inhibitor with anti-HCV and anti-HBV activities, suppresses HBV DNA and acts as an aryl hydrocarbon receptor (AhR) agonist.

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生物&药学活性

iCDM-34 is a small molecule inhibitor with anti-HCV and anti-HBV activities, suppresses HBV DNA and acts as an aryl hydrocarbon receptor (AhR) agonist.
iCDM-34 suppresses cellular HBV DNA levels with IC50 of 19.7 uM.
iCDM-34 (30 uM) inhibits medium HBV DNA, HBsAg, and HBeAg with showing a additive effect with entecavir (ETV) in primary cultured human hepatocytes.
iCDM-34 alone does not reduce HBV DNA in the liver, but the combination of iCDM-34 and ETV drastically suppresses the amount of HBV DNA in the liver compared with ETV alone.
iCDM-34 does not induce IFN signaling pathway and induces different characteristic signal pathways compared to CDM-3008 (Cat# PC-21583).
iCDM-34 induces AhR signaling, inhibits phosphorylation of SAMHD1 mediated by CDK1/2, suppresses CDK1/2 mRNA expression.

物理化学性质&存储条件

分子量	391.19
分子式	C14H11BrN6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-bromophenyl)-1-((4-nitro-1H-pyrazol-1-yl)methyl)-1H-pyrazole-3-carboxamide

参考文献

1. Yutaka Furutani, et al. Cell Death Discov. 2023 Dec 22;9(1):467.

iCDM-34 (iCDM34)

生物&药学活性

物理化学性质&存储条件

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iCDM-34 (iCDM34)

生物&药学活性

物理化学性质&存储条件

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