i4EG-BiP

Chemical Structure : i4EG-BiP

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货号: PC-24503Not For Human Use, Lab Use Only.

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

i4EG-BiP is a specific small molecule inhibitor of eukaryotic translation initiation factor 4E (eIF4E), displaces eIF4G peptide from eIF4E with IC50 of 68 uM, inhibits cap-dependent translation by increasing the eIF4E-4E-BP1 interaction, but not interaction of eIF4E with eIF4G.
i4EG-BiP binds to a new internal cavity on eIF4E, near the 4EGI-1 binding site.
i4EG-BiP impairs viability in MCF7 and MM1S cells.
i4EG-BiP inhibits cap-dependent translation better than 4EGI-1 in cellular assays.
i4EG-BiP disrupts the eIF4E-eIF4G and strengthens the eIF4E- 4E-BP1 interactions.

物理化学性质&存储条件

分子量	458.49
分子式	C24H18N4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-(4-([1,1'-biphenyl]-4-yl)thiazol-2-yl)hydrazineylidene)-3-(2-nitrophenyl)propanoic acid

参考文献

1. Fischer PD, et al. Eur J Med Chem. 2021 Jul 5;219:113435.

i4EG-BiP

生物&药学活性

物理化学性质&存储条件

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i4EG-BiP

生物&药学活性

物理化学性质&存储条件

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