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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-mTOR-eALM1192
eALM1192

Chemical Structure : eALM1192

CAS No.: 3134761-90-0

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eALM1192 (eALM-1192)

货号: PC-28445Not For Human Use, Lab Use Only.

eALM1192 is a highly potent and selective mTOR inhibitor with IC50 of 2.3 nM, 37-fold selectivity over DNA-PK and excellent kinome selectivity, exhibits sub-nanomolar (IC50=5.6 nM) antiproliferative activity for SW48 cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

eALM1192 is a highly potent and selective mTOR inhibitor with IC50 of 2.3 nM, 37-fold selectivity over DNA-PK and excellent kinome selectivity, exhibits sub-nanomolar (IC50=5.6 nM) antiproliferative activity for SW48 cells.

物理化学性质&存储条件

分子量 445.48
分子式 C23H23N7O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

prop-2-yn-1-yl 4-((4-amino-5-(2-aminobenzo[d]oxazol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)piperidine-1-carboxylate

参考文献

1. Lorente-Macías Á, et al. RSC Med Chem. 2026 Aug 13. doi: 10.1039/d6md00572a.

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