eALM1137 | mTOR inhibitor | Probechem Biochemicals

Chemical Structure : eALM1137

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eALM1137 (eALM-1137)

货号: PC-26526Not For Human Use, Lab Use Only.

eALM1137 is a highly potent, selective mTOR inhibitor with IC50 of 4.8 nM, weakly inhibits DNA-PK with IC50 of 77 nM (17-fold selectivity).

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生物&药学活性

eALM1137 is a highly potent, selective mTOR inhibitor with IC50 of 4.8 nM, weakly inhibits DNA-PK with IC50 of 77 nM (17-fold selectivity).
eALM1137 shows antiproliferative activity against GBM cell lines: U87-MG and T98G with IC50 of 5.1 nM and 11 nM.
eALM1137 does not inhibit PI3Kα, PKN3, CK1δ.
eALM1137 demonstrates dose-dependent dual inhibition of mTORC1 and mTORC2 activities, as shown by the reduction of S6 and Akt phosphorylation, respectively, at 30 nM and higher concentrations, in T98G and U87-MG cells.
eALM1137 treatment induces significant reduction in cell proliferation with an EC50 of 85 nM in triple mutant NPE cell line, which has a double deletion of NF1 and PTEN, and overexpression of EGFR in neural stem cells.
eALM1137 inhibits mTORC1 signaling, as evidenced by reduced phosphorylation of the S6 ribosomal protein (Ser235/236 and Ser240/244) and 4E-BP1 (Thr37/46).

物理化学性质&存储条件

分子量	450.50
分子式	C22H26N8O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Isopropyl 4-((4-amino-3-(2-aminobenzo[d]oxazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)piperidine-1-carboxylate

参考文献

1. Lorente-Macías Á, et al. J Med Chem. 2026 Apr 12. doi: 10.1021/acs.jmedchem.6c00541.

eALM1137 (eALM-1137)

生物&药学活性

物理化学性质&存储条件

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eALM1137 (eALM-1137)

生物&药学活性

物理化学性质&存储条件

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