dBAZ2B

Chemical Structure : dBAZ2B

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货号: PC-27853Not For Human Use, Lab Use Only.

dBAZ2B is a first-in-class Proteolysis Targeting Chimera (PROTAC) degrading BAZ2B, selectively degrades BAZ2B with DC50 of 19 nM and Dmax ≥ 97% in PC3 cells, does not affect BAZ2A.

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生物&药学活性

dBAZ2B is a first-in-class Proteolysis Targeting Chimera (PROTAC) degrading BAZ2B, selectively degrades BAZ2B with DC50 of 19 nM and Dmax ≥ 97% in PC3 cells, does not affect BAZ2A.

物理化学性质&存储条件

分子量	1028.26
分子式	C55H66FN11O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,4R)-N-(2-(((1r,4S)-4-(((5-(4-cyanophenyl)-4-(1-methyl-1H-pyrazol-4-yl)-1-(2-(1-methyl-1H-pyrazol-4-yl)ethyl)-1H-imidazol-2-yl)methoxy)methyl)cyclohexyl)methoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide

参考文献

1. Palaferri L, et al. ACS Med Chem Lett. 2025 Jan 7;16(2):234-240.

dBAZ2B

生物&药学活性

物理化学性质&存储条件

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dBAZ2B

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