dASK1-VHL

Chemical Structure : dASK1-VHL

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货号: PC-24880Not For Human Use, Lab Use Only.

dASK1-VHL is a potent, selective cereblon (CRBN)-based PROTAC degrader of apoptosis signal-regulating kinase 1 (ASK1).

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dASK1-VHL is a potent, selective cereblon (CRBN)-based PROTAC degrader of apoptosis signal-regulating kinase 1 (ASK1).
dASK1-VHL demonstrates robust ASK1 degradation within the concentration range of 10-100 nM, achieving a maximum reduction of 60% at 50 nM.
dASK1-VHL effectively reduced ASK1 protein levels, suppressed p38 MAPK activation, and decreased hepatic lipid content, indicating significant therapeutic benefits.

物理化学性质&存储条件

分子量	986.11
分子式	C48H57F2N11O8S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-(2,4-Difluoro-5-((6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)carbamoyl)phenyl)-N4-(2-(3-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)ethyl)succinamide

参考文献

1. Sarkar HS, et al. RSC Med Chem. 2025 Jun 6. doi: 10.1039/d5md00252d.

dASK1-VHL

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dASK1-VHL

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