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首页-小分子抑制剂&激动剂-Apoptosis-Receptor Interacting Protein Kinase (RIPK)-cRIPGBM chloride
cRIPGBM chloride

Chemical Structure : cRIPGBM chloride

CAS No.: 2361988-77-2

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cRIPGBM chloride (RIPGBM derivative cRIPGBM;RIPGBM-18)

货号: PC-36133Not For Human Use, Lab Use Only.

cRIPGBM (RIPGBM derivative cRIPGBM, RIPGBM-18) is a metabolite of RIPGBM induces apoptosis in GBM CSCs (EC50=68 nM in GBM 1 cells) by interacting with RIPK2 (Kd=2.3 uM).

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5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥1980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

cRIPGBM (RIPGBM derivative cRIPGBM, RIPGBM-18) is a metabolite of RIPGBM induces apoptosis in GBM CSCs (EC50=68 nM in GBM 1 cells) by interacting with RIPK2 (Kd=2.3 uM).
cRIPGBM induces caspase 1-dependent apoptosis, reduces the formation of a prosurvival RIPK2/TAK1 complex and increases the formation of a proapoptotic RIPK2/caspase 1 complex.

物理化学性质&存储条件

分子量 446.90
分子式 C26H20ClFN2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-benzyl-3-(4-fluorobenzyl)-2-methyl-4,9-dioxo-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium chloride

参考文献

1. Lucki NC, et al. Proc Natl Acad Sci U S A. 2019 Mar 7. pii: 201816626. doi: 10.1073/pnas.1816626116.

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