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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Cyclic GMP-AMP synthase (cGAS)-cGAS inhibitor cpd6
cGAS inhibitor cpd6

Chemical Structure : cGAS inhibitor cpd6

CAS No.:

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cGAS inhibitor cpd6

货号: PC-25369Not For Human Use, Lab Use Only.

cGAS inhibitor cpd6 is a potent, small moecule inhibitor of human cyclic GMP-AMP synthase (cGAS) with IC50 of 0.66 µM, modestly inhibits cGAMP levels by 29% at 30 µM in THP1 cells without detectable toxicity, and by 76% at 100 µM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

cGAS inhibitor cpd6 is a potent, small moecule inhibitor of human cyclic GMP-AMP synthase (cGAS) with IC50 of 0.66 µM, modestly inhibits cGAMP levels by 29% at 30 µM in THP1 cells without detectable toxicity, and by 76% at 100 µM.

物理化学性质&存储条件

分子量 524.17
分子式 C16H15BrINO4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-((3-bromo-4-ethoxyphenyl)sulfonyl)-2-(4-iodophenyl)acetamide

参考文献

1. Alarcón-Espósito J, et al. bioRxiv [Preprint]. 2025 Aug 22:2025.08.18.670979.

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