Bisperoxovanadium (bpV(phen) potassium hydrate) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 =38 nM), also inhibits the vascular endothelial PTP, PTP-β (IC50=343 nM), and PTP-1β (IC50=920 nM).
Bisperoxovanadium (bpV(phen) potassium hydrate) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 =38 nM), also inhibits the vascular endothelial PTP, PTP-β (IC50=343 nM), and PTP-1β (IC50=920 nM).
Bisperoxovanadium activates the insulin receptor tyrosine kinase and promotes downstream signaling, including activation of PI3-kinase.
物理化学性质&存储条件
分子量
404.3
分子式
C12H8N2O5V • K+(H2O)3
外观性状
Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
参考文献
1. Castaldi L, et al. FASEB J. 2007 Nov;21(13):3573-83.
2. Paliwal P, et al. Chem Biol. 2011 Sep 23;18(9):1153-66.
3. Lai JP, et al. Br J Pharmacol. 2007 Dec;152(8):1172-84.
