b-AP15 (bAP15, NSC 687852)

Chemical Structure : b-AP15

CAS No.: 1009817-63-3

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货号: PC-20656Not For Human Use, Lab Use Only.

b-AP15 (bAP15, NSC 687852) is a specific inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), inhibits DUB activity in purified 19S proteasomes with IC50 of 2.1 uM.

规格	价格	库存
10 mg	￥580	In stock
25 mg	￥980	In stock
50 mg	￥1480	In stock
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

b-AP15 (bAP15, NSC 687852) is a specific inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), inhibits DUB activity in purified 19S proteasomes with IC50 of 2.1 uM.
b-AP15 exhibits little or no activity against several other DUBs.
b-AP15 induces tumor cell apoptosis that is insensitive to TP53 status and overexpression of the apoptosis inhibitor BCL2, blocks growth and induces apoptosis in MM cells.
b-AP15 blocks tumor progression in vivo in mice and prevents organ infiltration in mouse models of myeloid leukemia.

物理化学性质&存储条件

分子量	419.39
分子式	C22H17N3O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3E,5E)-3,5-Bis[(4-nitrophenyl)methylene]-1-(1-oxo-2-propen-1-yl)-4-piperidinone

参考文献

1. D'Arcy P, et al. Nat Med. 2011 Nov 6;17(12):1636-40.

2. Wang X, et al. Mol Pharmacol. 2014 Jun;85(6):932-45.

3. Tian Z, et al. Blood. 2014 Jan 30;123(5):706-16.