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首页-抗体和重组蛋白-Biosimilar Antibody-Zolbetuximab
Zolbetuximab

Chemical Structure : Zolbetuximab

CAS No.: 1496553-00-4

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Zolbetuximab (Anti-human Claudin 18.2 mAb, human IgG1-Kappa)

货号: PC-Ab1015Not For Human Use, Lab Use Only.

Zolbetuximab is a first-in-class chimeric IgG1 mAb that specifically binds to Claudin 18 splice variant 2 (CLDN18.2) on the cell surface and mediates cell death through antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity. Claudin-18 (CLDN18) is a highly specific TJ component of the stomach. It is expressed in foetal and in adult normal gastric mucosa.

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1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Zolbetuximab is a first-in-class chimeric IgG1 mAb that specifically binds to Claudin 18 splice variant 2 (CLDN18.2) on the cell surface and mediates cell death through antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity. Claudin-18 (CLDN18) is a highly specific TJ component of the stomach. It is expressed in foetal and in adult normal gastric mucosa

物理化学性质&存储条件

分子量
分子式 Human IgG1-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Zolbetuximab; IMAB362; Claudiximab; iMAB-362; CLDN18.2; Claudin 18 splice variant 2

参考文献

1. 1, Ajaz A. Bhat, et al. Mol Cancer. 2021; 20: 2. Published online 2021 Jan 4. 2, Oncol Lett. 2020 Jun; 19(6): 3665–3670. 3, Irene Coati, et al. Irene Coati,  4, Türeci Ӧ, et al. Oncoimmunology. 2019; 8(1):e1523096.

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